That's tied for the most outright wins without a loss in any matchup in NFL history, according to Elias Sports Bureau research. -- Courtney Cronin. Since Chicago isnt a huge threat with its receivers, the defense will focus on Tarik Cohen and Jordan Howard in the running game. Overall, Minnesota is tied for eighth in points allowed (19.0) and third in rushing yards allowed (71.3). Walder's pick: Eagles 23, Cardinals 20 Paired with fellow receivers John Brown and Jaron Brown, the Arizona wideouts pose a threat to a vulnerable Eagles cornerback group. Week 5 NFL predictions: Scores for every game - NFL Nation- ESPN Matchup rating: 44.9 | Spread: CHI -5 (40.5), What to watch for: Khalil Mack will be looking to take over the game against his former teammates. Betting nugget: Brandon Staley is 1-3 outright and ATS as a road favorite (won last week). -- Eric Woodyard. Read more. Quarterback Jacoby Brissett has led the Colts to more than 30 points in a game only once in 19 starts, and that was 31 points in his second start back in Week 3 of the 2017 season. Gutierrez's pick: Bears 20, Raiders 16 Colts vs Broncos starts the week off on Thursday Night Football. What to know for fantasy: Curtis Samuel's target share is nearly twice that of DJ Moore (24.1% to 12.1%) with Kyle Allen under center for the Panthers this season. Finally, Seth Walder and Eric Moody give us final score picks for every game. Veteran WR Cole Beasley retires after 11 NFL seasons, What to watch for: Rookie quarterback Kenny Pickett is set to make his first career start against a Bills defense that is tied with the San Francisco 49ers for giving up the fewest yards per game (234.5). Barshop's pick: Texans 20, Falcons 17 Yes, he's 2-0, but the Saints will need more from Bridgewater, 1 p.m. The Cowboys will want to prove last week was more of a fluke than a trend. Matchup rating: 50.5 | Spread: BAL -3.5 (44), What to watch for: The Ravens' defense has a penchant for giving up big plays. The Raiders . Stat to know: Jacoby Brissett is fifth in both QBR (75) and completion percentage (74%) in home games this season. What to know for fantasy: The Raiders' Tyrell Williams is the only player with a touchdown reception in all four weeks thus far and has seen five of Oakland's six end zone targets this season. See Week 5 rankings. Stat to know: Chargers receiver Keenan Allen leads the NFL with 452 receiving yards, and he is the only player with more than 400. Everything you need to know for the draft Stat to know: The Patriots are looking to become the first team since the 1988 Browns and Dolphins to allow zero passing touchdowns in the first five games of the season. Matchup rating: 52.4 | Spread: NE -15 (42), What to watch for: Can the Redskins do anything to slow the Patriots' offense? Davenport's pick: Titans 17, Bills 14 See Week 5 rankings. The NFL reporter use his Twitter account to share insight about the league's upcoming 2023 schedule . Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. NFL SPREAD TO WIN TOTAL Philadelphia Eagles -5.5 -227 o49 Arizona Cardinals +5.5 +175 u49 49ers 37, Panthers 15 Point spread: 49ers (-6.5) cover by winning by more than 6.5 points. UPDATE: I made seven changes to my final mock draft -- starting with the No. -- Rich Cimini. Plus, Antonio Brown is angry and wants the ball, which means he's due for a big game. Lions 28, Panthers 20 -- Michael Rothstein, This is the second of three consecutive road games for the Niners, and they're coming off a trio of games they lost by a combined eight points. More NFL coverage , Bold prediction: The Bucs will hold Alvin Kamara under 100 all-purpose yards and under 45 rushing yards. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. Things are lined up -- on paper at least -- for the 49ers to get their first victory of the season. The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. What to know for fantasy: Derek Carr has completed over 70% of his passes in four straight games against the Chiefs and cleared 18 fantasy points in three of those contests. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. However, Miami is vastly improved in that area, allowing just 3.1 yards per rush and 78 yards per game this season. FREE to play! This should be a prime spot for them to get on track, even with the uncertainty surrounding receiver Stefon Diggs. Which QB will Colts take in Round 1? It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. But to this point, Steelers quarterback Mason Rudolph hasn't been able to take advantage of the vertical game, averaging just 3.3 air yards per completion, the lowest for any quarterback with 50 completions since 2006. Tennessee adopted a quick-hitting passing attack last week to speed up Mariota's decision-making, which should be the way to go against a Bills defense that takes away the vertical passing game and is third in the league in allowing a 57.1 completion percentage. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. They have the NFL's second-ranked rushing defense, surrendering only 59.3 yards per game, and they held Christian McCaffrey to just 37 rushing yards in Week 2 (53 all-purpose yards) and the Rams to just 28 total rushing yards in Week 4. The Bucs also gave up an uncharacteristic 189 rushing yards in their 41-31 loss to the Kansas City Chiefs last week -- the most they've surrendered since 2018. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL. -- Jamison Hensley. Stat to know: Brady's only three-game losing streak in his career came from Weeks 4 to 8 in 2002, his second season as a starter. TB-NO | ATL-HOU | BUF-TEN Getting back to what they do best -- stopping the run -- is paramount this week. They're now +1.5. And regardless of whos at quarterback, Adam Thielen and Stefon Diggs need to spark the Vikings' aerial attack early while the running game gets in its groove with Latavius Murray taking the reins for an injured Dalvin Cook. Betting nugget: Over the past five seasons, Miami is 13-7 ATS as a favorite. Stat to know: The Dolphins' 11-2 record since 2021 Week 9 is tied with the Chiefs for best in the NFL. Atlanta is the only team this season undefeated against the spread. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . Week 5 NFL predictions: Game Postponed. With a banged-up Steelers defense that has struggled since T.J. Watt's Week 1 injury, this game has the potential for any number of Buffalo offensive superlatives. That should change against a Tampa Bay team that is averaging 31 points per game and allowing 29. CFB: The way-too-early top 25 for 2021 Matchup rating: 77.2 | Spread: DAL -3.5 (46.5), What to watch for: Can the Packers' defense replicate what New Orleans did a week ago in holding Ezekiel Elliott to 35 yards on 18 carries? They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). For the season on third downs, he's completing only 48.9% of his passes and owns a 78.0 passer rating. After a first round that saw three quarterbacks taken high, the Texans get aggressive, Will Levis slide . This season, Cooks has zero 100-yard receiving games and has averaged just 53 yards per game. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. What to know for fantasy: Austin Ekeler scored more fantasy points last week in Houston (34.9) than he did in the two weeks prior combined (31.7). The Week 5 NFL slate is stacked with great matchups. While he acquitted himself generally well in a tough spot when Mailata went down against the Jaguars on Sunday, Arizona should have some opportunities to affect the passer. Click on each game for the game preview and CFN Prediction Week 5 NFL Expert Picks Stat to know: The Rams have been outscored 44-3 with an NFL-worst minus-41 point differential in the fourth quarter this season -- they have outscored opponents by 17 in the first three quarters. Betting nugget: This game has the highest over/under this season. But its not like Rodgers needs time to get ready to face a Rod Marinelli-coached defense. The Rams took their first loss, and the. -- Mike Reiss, Bold prediction: Lions running back Jamaal Williams will rush for at least two touchdowns. -- Marcel Louis-Jacques. Moody's pick: 49ers 27, Panthers 10 Sure, the Packers have found replacements for all three, but those were big-time players who performed in the clutch. Chargers 20, Giants 19 -- Eric Williams, The Giants are at home in a game they badly need to keep from imploding. What to know for fantasy: Pierce has more than 100 scrimmage yards and a rushing score in consecutive games. Arizona has given up 17 sacks while the Eagles have 10 on the season, but Palmer called the Eagles' front seven one of the best he will face this year. Betting nugget: Mahomes is 7-1 outright and 6-2 ATS against Las Vegas. McManus' pick: Steelers 24 . Gregg Rosenthal. -- Sarah Barshop, Bold prediction: The Falcons, who have been outscored 38-10 in first quarters this season, will actually have the lead after the first frame in Houston. DiRocco's pick: Panthers 17, Jaguars 16 ET | NFL Network NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . See Week 5 rankings. -- Brooke Pryor, NFL PrimeTime continues this postseason with extended highlights and analysis following the conclusion of each day's playoff games. Betting nugget: All four Bills games have gone under the total this season. That would mean bigger roles for undrafted rookie Keelan Cole (four catches) and recently signed first-year player Max McCaffrey. He is tied with Russell Wilson for the most in the NFL in that span. But Joe Flacco's struggles (one touchdown in his past 28 drives) and Baltimore's poor history traveling out west (five consecutive losses) make it difficult to have any confidence in the Ravens. ET | CBS See Week 5 rankings. It wouldn't be a shock if they underestimate the Browns, but they have too many matchups in their favor to lose the game. Stat to know: The Chiefs have won six straight home games on Monday Night Football with the last loss coming in 2004 against the Patriots. Transactions | Injuries And the Chargers have allowed 5.4 yards per rush, the second worst in the NFL. Even without D'Andre Swift, the Lions' ground attack is rolling, and that won't stop against New England. FPI prediction: CAR, 56.2% (by an average of 1.8 points), Matchup must-reads: Jimmie Ward year away from being among rarefied 49ers company Mayfield struggles, but Panthers don't have another option Nick Bosa says 49ers' defense has personnel to be 'best in the league' Mayfield takes blame for offense's struggles amid 1-3 start Darnold's return from IR not close, coach Matt Rhule says, 4:25 p.m. See Week 5 rankings. However, Arizona's primary hope for winning this game lies with its run defense. What to know for fantasy: Derrick Henry has nine straight games with either over 100 total yards or a rushing touchdown. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. -- Paul Gutierrez. Baltimore's defense has struggled, and the amount of damage opposing teams have done through the air bodes well for the Bengals and Chase, who has received extra attention from opposing teams this season. Stat to know: The Vikings have allowed at least 300 yards in 12 straight games dating back to last season. Through four games, they have collected an NFL-low 390 passing yards -- the fourth fewest by any team at this point in a season since 2000. 2023 NFL Draft props, picks: Michael Mayer Under 23.5 He started slow, but has run for 199 yards combined the past two weeks and ranks third in the NFL in yards after first contact at 3.21 in that time. The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions. I tweaked my predictions from Sunday to reflect . FPI prediction: GB, 86.9% (by an average of 13.5 points), Matchup must-reads: How Saquon Barkley and AJ Dillon became the 'Quad Kings' of the NFL Landon Collins, Giants finalizing deal, sources say Packers' Aaron Rodgers wanted longer London trip Rodgers: 'This way of winning, I don't think, is sustainable', What to know for NFL Week 5: Score picks, bold predictions, fantasy tips, key stats for all 15 games, Which NFL teams still have roster holes? Lamb has been targeted 42 times with 23 catches for 288 yards. -- David Newton, Bold prediction: McCaffrey surpasses 100 yards rushing and receiving. His 43.1 QBR this season is also his worst through the first four games in that same time frame. What to know for fantasy: Christian McCaffrey has set the bar so high that three straight games with more than 100 scrimmage yards isn't enough to put him in the good graces of fantasy managers. -- Turron Davenport. Projecting the Giant's first-round pick, Moody's pick: Saints 27, Seahawks 24 That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. NFL Nation reporters predict the outcomes and scores for Sunday's and Monday's Week 5 games. See Week 5 rankings. Stat to know: Allen has accounted for all 12 of the Bills' offensive touchdowns this season (either pass or scored).
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