Synergistic transcriptional activation of human acyl-coenzyme A:cholesterol acyltransterase-1 gene by interferon- and all-trans-retinoic acid THP-1 cells. Nat. 38, 710716 (2003). Ayden Harrison. NPC1 is ubiquitously expressed and localizes on lysosomal membrane. Google Scholar. The authors thank Lu-Yi Jiang and Yun-Feng Li for drafting the original figures. Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. Sci. Escola-Gil, J. C. et al. They are responsible for menaquinone and ubiquinone biosynthesis, or protein modification called prenylation that is the covalent linkage of a lipid consisting of three or four isoprene units to a thiol of a cysteine side chain. Guo, Z. Y., Lin, S., Heinen, J. Genomics 65, 137145 (2000). J. Biol. & DeBose-Boyd, R. A. Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi. 15, e1008289 (2019). Chem. Cannon, C. P. et al. Chem. Proc. and JavaScript. Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor. Basic Res. Bromination-Debromination of Cholesterol | Free Essay Example The LXRIdol axis differentially regulates plasma LDL levels in primates and mice. Natl Acad. Eur. Melton, E. M. et al. Fitzgerald, M. L., Mujawar, Z. 294, 1583615849 (2019). Two tyrosine-based, iodine-containing hormones produced by the thyroid gland. J. Physiol. Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible degrader of the LDLR (IDOL). Evidence for a NiemannPick C (NPC) gene family: identification and characterization of NPC1L1. Chem. 289, 2402024029 (2014). 23, 39 (2016). Vasc. Buhman, K. K. et al. Extracellular loop C of NPC1L1 is important for binding to ezetimibe. A metabolite of vitamin A1 (all-trans-retinol). Jiang, S. Y. et al. Alllylic bromination of 1-butene. in The Metabolic and Molecular Bases of Inherited Disease 8th edn (eds Scriver, C. R., Beaudet, A. L., Sly, W. S., & Valle, D.) 36113633 (McGraw-Hill, 2001). https://doi.org/10.1038/s41580-019-0190-7. A large (1278 amino acids in humans), 13-pass transmembrane protein that binds cholesterol with the 3-hydroxyl group and thetetracyclic ring of cholesterol buried and the iso-octyl side chain exposed via the N-terminal domain. Davis, H. R. et al. Cell Metab. The sterol-sensitive transcription factors that belong to the nuclear receptor family and are activated by oxysterols and desmosterol. Sumi, K. et al. Biol. Internet Explorer). J. Steroid Biochem. Tarling, E. J. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. Wong, L. H., Gatta, A. T. & Levine, T. P. Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes. Chem. 294, 81348147 (2019). Yue, S. H. et al. The cellular cholesterol level reflects the dynamic balance between biosynthesis, uptake, export and esterification a process in which cholesterol is converted to neutral cholesteryl esters either for storage in lipid droplets or for secretion as constituents of lipoproteins. USA 104, 65116518 (2007). Arterioscler. Li, D. et al. The interface formed between an antigen-presenting cell or target cell and a lymphocyte such as a T cell, B cell or natural killer cell. J. Lipid Res. Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver. Atherosclerosis 211, 361370 (2010). Biol. & Dong, X. C. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. 51, 13541362 (2010). Chem. USA 100, 31553160 (2003). Biochem. Kikuchi, T. et al. Rogers, M. A. et al. N. Engl. Work from the B.-L.S. Moon, S. H. et al. Pharmacol. Song, B. L. et al. 111, 967981 (2012). E2enzymes perform thesecond step in the ubiquitylation reaction. Vasc. Why use glacial acetic acid in bromination of anisole? Drug Metab. Kawase, A., Araki, Y., Ueda, Y., Nakazaki, S. & Iwaki, M. Impact of a high-cholesterol diet on expression levels of NiemannPick C1-like 1 and intestinal transporters in rats and mice. Glerup, S., Schulz, R., Laufs, U. Weinglass, A. Opin. Genet. Abstraction of hydrogen by a bromine atom is endothermic in both cases. Endocrinol. Sever, N., Yang, T., Brown, M. S., Goldstein, J. L. & DeBose-Boyd, R. A. Cholesterol is an essential component of cell membranes and the precursor for the synthesis of steroid hormones and bile acids. Google Scholar. Lee, J. N., Gong, Y., Zhang, X. Y. NUMB further recruits AP2clathrin to initiate endocytosis. The LXRIDOL axis defines aclathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation. This work identifies an LXR-responsive lncRNA, MeXis, and shows that it enhances ABCA1 expression and macrophage cholesterol efflux. A diterpene alcohol containing 20 carbons that is synthesized in the mevalonate pathway. wrote the Review and H.Y. 282, 1860218612 (2007). 11, 367383 (2012). After depletion of their triglycerides by the extrahepatic tissues, chylomicrons become chylomicron remnants that arecleared by the liver. Biophys. Annu. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Proc. J. Lipid Res. This is a preview of subscription content, access via your institution. laboratory is supported by grants from the National Natural Science Foundation of China (91753204, 31600651, 31690102, 91857000 and 31771568) and the Ministry of Science and Technology of China (2016YFA0500100 and 2018YFA0800700). 26, 8287 (2015). NPC1L1-deficient mice absorb much less cholesterol and are insensitive to ezetimibe, a cholesterol absorption inhibitor. 31, 11081115 (2011). eLife 5, e21635 (2016). Chem. & Porter, T. D. Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Mol. J. Biol. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBPfamily of transcription factors by SCFFbw7. Proc. 286, 3019030199 (2011). Gelissen, I. C. et al. mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells. 310, G618G628 (2016). Biol. Proc. Eid, W. et al. et al. Cholesterol is superior to 7-ketocholesterol or 7-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. Google Scholar. 53, 95104 (2012). J. 60, 17651775 (2019). Mechanisms and regulation ofcholesterol homeostasis. Arterioscler. 1, 379391 (2005). USA 108, 1971919724 (2011). Zhang, D. Q. et al. J. Biol. FEBS Lett. Nature 343, 425430 (1990). 293, 312323 (2018). 275, 2824028245 (2000). 33, 15031514 (2013). Henderson, R., OKane, M., McGilligan, V. & Watterson, S. The genetics and screening of familial hypercholesterolaemia. Bartuzi, P. et al. USA 95, 59875992 (1998). Biol. Biol. A. Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interactswith AP-2. Repa, J. J., Buhman, K. K., Farese, R. V., Dietschy, J. M. & Turley, S. D. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Experiment 5 - Bromination of Cholesterol. Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. Cao, J. et al. 273, 3513235141 (1998). Complex structure of the fission yeast SREBPSCAP binding domains reveals an oligomeric organization. Padyana, A. K. et al. BMB Rep. 46, 322327 (2013). A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes. J. Biol. 292, 30163028 (2017). Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Commun. Schoebel, S. et al. The advantage of the bromine-Sudan Black . Liver Physiol. Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. & Rudel, L. L. Identification of putative active site residues of ACAT enzymes. Proc. To this solution is added dropwise a solution (c. 8 ml) of bromine in a acid containing sodium acetate via syringe. Yabe, D., Xia, Z. P., Adams, C. M. & Rawson, R. B. microRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Chem. Hagita, S. et al. Sci. Bromination and Debromination of Cholesterol: An Inquiry-Based Lab Biochim. Hepatocyte nuclear factor 1 plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine. PLOS Genet. Zhao, K. & Ridgway, N. D. Oxysterol-binding protein-related protein 1L regulates cholesterol egress from the endo-lysosomal system. USA 108, 2050320508 (2011). Chu, B. J. Biol. Through the series of reactions of E1, E2 and E3, cellular proteins are linked to ubiquitin.
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